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The primary analyses will be based on mixed models which use all available data on individuals, are flexible in accounting for the correlation structure among observations on the same individual and provide unbiased and efficient estimates when the data are missing at random

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With these new proposed cigarette health warnings, we have an enormous public health opportunity to fulfill our statutory mandate and increase the publics understanding of the full scope of serious negative health consequences of cigarette smoking. Health warnings first appeared on cigarette packages in 1966 and were most recently updated in 1984 to include the Surgeon Generals warnings that appear on packages and in advertisements today